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The traditional way of taking a drug, such as a pill or injection, often results in plasma drug levels that cycle between too high and too low. To better maintain drug levels in the effective range, scientists have developed a variety of systems to optimize drug release. In his first talk, Bob Langer gives an overview of many of these controlled drug release technologies, including polymer and pump systems. Langer begins Part 2 with the story of how he became interested in drug release technologies, which is also a story of the power of perseverance. As a post-doc with Judah Folkman, and after much trial and error, Langer developed a polymer system that provided a slow and constant release of an anti-angiogenesis factor. Initially, his results were met with skepticism, by both scientists and the patent office. Today, many, many companies have developed peptide delivery systems based on that original work. Langer also describes ongoing research in areas such as targeted drug delivery and externally controlled microchips designed for drug delivery. In Part 3, Langer focuses on the materials used in drug delivery and medical devices. Many of the original materials used in medicine were adapted from completely unrelated uses and often generated their own problems. Langer describes work by his lab and others to make polymers designed for specific medical uses. For instance, a porous polymer can be shaped into an ear or nose and act as a scaffold onto which a patient’s cells can be seeded to grow a new structure. Different polymers have been successfully used as scaffolds to grow new blood vessels or artificial skin for burn victims.
- Subjects:
- Health Technology and Informatics and Health Sciences
- Keywords:
- Drugs -- Controlled release Controlled release technology
- Resource Type:
- Video
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Video
Childhood trauma isn’t something you just get over as you grow up. Pediatrician Nadine Burke Harris explains that the repeated stress of abuse, neglect and parents struggling with mental health or substance abuse issues has real, tangible effects on the development of the brain. This unfolds across a lifetime, to the point where those who’ve experienced high levels of trauma are at triple the risk for heart disease and lung cancer. An impassioned plea for pediatric medicine to confront the prevention and treatment of trauma, head-on.
- Subjects:
- Health Sciences
- Keywords:
- Child mental health Psychic trauma in children
- Resource Type:
- Video
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Video
In 47 episodes, Hank Green will teach you anatomy and physiology! This course is based on an introductory college level curriculum, with Human Anatomy and Physiology, 9th edition, by Marieb and Hoehn as its main reference text. By the end of the course, you will be able to: * Understand the chemistry and cell biology of systems in the human body * Recognize how tissue types define the function of each organ system * Predict how the failure of an organ system might lead to disease * Explain how energy is changed into different forms throughout the body * Break down the names of anatomical systems using Greek and Latin root words We also made flashcards to help you review the content in this course! Find them on the free
- Subjects:
- Health Sciences
- Keywords:
- Human physiology Human anatomy
- Resource Type:
- Video