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Irina Kareva translates biology into mathematics and vice versa. She writes mathematical models that describe the dynamics of cancer, with the goal of developing new drugs that target tumors. "The power and beauty of mathematical modeling lies in the fact that it makes you formalize, in a very rigorous way, what we think we know," Kareva says. "It can help guide us to where we should keep looking, and where there may be a dead end." It all comes down to asking the right question and translating it to the right equation, and back.
- Subjects:
- Health Sciences and Mathematics and Statistics
- Keywords:
- Cancer -- Mathematical models Cancer cells -- Mathematical models
- Resource Type:
- Video
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Video
The things we eat and drink on a daily basis can impact our health in big ways. Too many carbohydrates, for instance, can lead to insulin resistance, which is a major contributor to cardiovascular disease and Type 2 Diabetes. But what are carbs, exactly? And what do they do to our bodies? Richard J. Wood explains.
- Subjects:
- Health Sciences and Food Science
- Keywords:
- Carbohydrates Nutrition
- Resource Type:
- Video
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Video
Sue Desmond-Hellmann is using precision public health -- an approach that incorporates big data, consumer monitoring, gene sequencing and other innovative tools -- to solve the world's most difficult medical problems. It's already helped cut HIV transmission from mothers to babies by nearly half in sub-Saharan Africa, and now it's being used to address alarming infant mortality rates all over the world. The goal: to save lives by bringing the right interventions to the right populations at the right time.
- Subjects:
- Health Sciences and Biology
- Keywords:
- Medicial informatics Big data Public health
- Resource Type:
- Video
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Video
Your lifelong health may have been decided the day you were born, says microbiome researcher Henna-Maria Uusitupa. In this fascinating talk, she shows how the gut microbes you acquire during birth and as an infant impact your health into adulthood -- and discusses new microbiome research that could help tackle problems like obesity and diabetes.
- Subjects:
- Health Sciences and Biology
- Keywords:
- Microorganisms Medical genetics
- Resource Type:
- Video
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Video
Easy access to nutrients has contributed to the increase in obesity in the human population. But, what is obesity and why isn’t everybody fat? Dr. Stephen O’Rahilly provides a biomedical perspective of obesity, and evaluates which genes could potentially shift the balance towards obesity. As he explains, one becomes obese when the balance between energy intake and energy spent is shifted. Surprisingly, mutations that lead to obesity in humans aren’t in genes involved in metabolism and energy storage, but failure in satiety signals in the brain that result in people eating too much. The excess of energy intake over energy expenditure leads to obesity. What is the consequence of obesity in human health? Physically, obesity can result in lower mobility and sleeping disorders. But, in humans, the link between obesity and metabolic diseases isn’t straightforward. For example, not everyone that’s obese becomes insulin resistant. As O’Rahilly explains, the probability of an obese individual to have a metabolic disease is linked to the capacity of adipose tissue to store the extra fat. Mutations that decrease fat storage in adipose tissue increase the chance of metabolic diseases, like insulin resistance, even when the person is not obese.
- Subjects:
- Health Sciences and Biology
- Keywords:
- Obesity -- Genetic aspects
- Resource Type:
- Video