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Video
Models arising in biology are often written in terms of Ordinary Differential Equations. The celebrated paper of Kermack-McKendrick (19271, founding mathematical epidemiology, showed the necessity to include parameters in order to describe the state of the individuals, as time elapsed after infection. During the 70s, many mathematical studies were developed when equations are structured by age, size, more generally a physiological trait. The renewal, growth-fragmentation are the more standard equations. The talk will present structured equations, show that a universal generalized relative entropy structure is available in the linear case, which imposes relaxation to a steady state under non-degeneracy conditions. In the nonlinear cases, it might be that periodic solutions occur, which can be interpreted in biological terms, e.g., as network activity in the neuroscience. When the equations are conservation laws, a variant of the Monge-Kantorovich distance (called Fortet-Mourier distance) also gives a general non-expansion property of solutions.
Event date: 19/1/2023
Speaker: Prof. Benoît Perthame (Sorbonne University)
Hosted by: Department of Applied Mathematics
- Subjects:
- Biology and Mathematics and Statistics
- Keywords:
- Biomathematics Equations
- Resource Type:
- Video
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Video
Irina Kareva translates biology into mathematics and vice versa. She writes mathematical models that describe the dynamics of cancer, with the goal of developing new drugs that target tumors. "The power and beauty of mathematical modeling lies in the fact that it makes you formalize, in a very rigorous way, what we think we know," Kareva says. "It can help guide us to where we should keep looking, and where there may be a dead end." It all comes down to asking the right question and translating it to the right equation, and back.
- Subjects:
- Health Sciences and Mathematics and Statistics
- Keywords:
- Cancer -- Mathematical models Cancer cells -- Mathematical models
- Resource Type:
- Video
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Video
Physicist Geoffrey West has found that simple, mathematical laws govern the properties of cities -- that wealth, crime rate, walking speed and many other aspects of a city can be deduced from a single number: the city's population. In this mind-bending talk from TEDGlobal he shows how it works and how similar laws hold for organisms and corporations.
- Subjects:
- Environmental Engineering and Mathematics and Statistics
- Keywords:
- Cities towns -- Growth -- Econometric models Sustainable urban development
- Resource Type:
- Video
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Courseware
This course is intended for both mathematics and biology undergrads with a basic mathematics background, and consists of an introduction to modeling biological problems using continuous ODE methods (rather than discrete methods as used in 113A). We describe the basic qualitative behavior of dynamical systems in the context of a simple population model and, as time allows, introduce other types of models such as chemical reactions inside the cell or excitable systems leading to oscillations and neuronal signals. Certain topics from linear algebra that are needed for this course are presented as well, so a linear algebra prerequisite is not necessary.
- Subjects:
- Mathematics and Statistics and Biology
- Keywords:
- Biology -- Mathematical models
- Resource Type:
- Courseware