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Courseware
Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
- Subjects:
- Chemistry and Biology
- Keywords:
- Chemistry Organic Biochemistry
- Resource Type:
- Courseware
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Courseware
Antibodies, antigens, antigen-antibody reactions, cells and tissues of lymphoreticular and hematopoietic systems, and individual and collective components of cell-mediated and humoral immune response,
- Subjects:
- Biology
- Keywords:
- Hematology Immunology
- Resource Type:
- Courseware
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Courseware
Cell biology, biochemistry, genetics, and the biology of organ systems, Covers concepts of building blocks (nucleotides, amino acids, and cells) and of information flow (DNA to proteins, receptors to nuclei, the blood to distant organs, and DNA to offspring)
- Subjects:
- Biology
- Keywords:
- DNA Biochemistry Cytology Biology
- Resource Type:
- Courseware
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Courseware
Patterns of diversity, ecology, and evolutionary biology. Emphasis is on the Tree of Life and how its members are distributed and interact. Partial Course.
- Subjects:
- Biology
- Keywords:
- Biodiversity Ecology Evolution (Biology)
- Resource Type:
- Courseware
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Courseware
Provides students with the basic tools for analyzing experimental data, properly interpreting statistical reports in the literature, and reasoning under uncertain situations. Topics organized around three key theories: Probability, statistical, and the linear model. Probability theory covers axioms of probability, discrete and continuous probability models, law of large numbers, and the Central Limit Theorem. Statistical theory covers estimation, likelihood theory, Bayesian methods, bootstrap and other Monte Carlo methods, as well as hypothesis testing, confidence intervals, elementary design of experiments principles and goodness-of-fit. The linear model theory covers the simple regression model and the analysis of variance. Places equal emphasis on theory, data analyses, and simulation studies.
- Subjects:
- Mathematics and Statistics and Biology
- Keywords:
- Statistics Cognitive science
- Resource Type:
- Courseware
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Courseware
With the growing availability and lowering costs of genotyping and personal genome sequencing, the focus has shifted from the ability to obtain the sequence to the ability to make sense of the resulting information. This course is aimed at exploring the computational challenges associated with interpreting how sequence differences between individuals lead to phenotypic differences in gene expression, disease predisposition, or response to treatment.
- Subjects:
- Computing and Biology
- Keywords:
- Genomics Genomes
- Resource Type:
- Courseware
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Courseware
The aim of this class is to introduce the exciting and often under appreciated discoveries in RNA biology by exploring the diversity of RNAs—encompassing classical molecules such as ribosomal RNAs (rRNAs), transfer RNAs (tRNAs) and messenger RNAs (mRNAs) as well as newer species, such as microRNAs (miRNAs), long-noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). For each new class of RNA, we will evaluate the evidence for its existence as well as for its proposed function. Students will develop both a deep understanding of the field of RNA biology and the ability to critically assess new papers in this fast-paced field. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
- Subjects:
- Biology
- Keywords:
- RNA
- Resource Type:
- Courseware
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Courseware
In this course, we will investigate the diverse types and functions of different RNA species, with a focus on "non-coding RNAs," i.e. those that do not directly encode proteins. The course will convey both the exciting discoveries in and frontiers of RNA research that are propelling our understanding of cell biology as well as the intellectual and experimental approaches responsible. The molecular biology revolution firmly established the role of DNA as the primary carrier of genetic information and proteins as the primary effector molecules of the cell. The intermediate between DNA and proteins is RNA, which initially was regarded as the "molecule in the middle" of the central dogma. This view has been transformed over the past two decades, as RNA has become recognized as a critical regulator of cellular processes.
- Subjects:
- Biology
- Keywords:
- Non-coding RNA RNA
- Resource Type:
- Courseware
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Courseware
How do we sense hunger? How do we sense pain? What causes growth in our bodies? How are we protected from pathogens? The answer to many of these questions involves small polymers of amino acids known as peptides. Peptides are broadly used as signal molecules for intercellular communication in prokaryotes, plants, fungi, and animals. Peptide signals in animals include vast numbers of peptide hormones, growth factors and neuropeptides. In this course, we will learn about molecular bases of peptide signaling. In addition, peptides potentially can be used as potent broad-spectrum antibiotics and hence might define novel therapeutic agents.
- Subjects:
- Biology
- Keywords:
- Peptides
- Resource Type:
- Courseware
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Courseware
Parasites require a hospitable organism to reproduce and spread and have evolved multiple strategies to subvert their hosts. Parasites scavenge nutrients directly from host cells, evade the host immune system and even modify host behavior to increase their transmission. This course will explore the strategies used by a ubiquitous and harmful class of parasites to hijack the biology of their host cells. We will discuss pathogens such as Plasmodium and Toxoplasma, responsible for some of the deadliest and most pervasive infectious diseases on the planet. By exploring how these pathogens invade a host cell and replicate while evading the immune system, students will gain a broad understanding of basic cell biology, biochemistry and immunology, as well as learn techniques commonly used in cell biology. Students will be challenged to think creatively and flexibly to understand, critique, interpret, and design scientific experiments in the field of host-pathogen interactions.
- Subjects:
- Biology
- Keywords:
- Pathogenic microorganisms Parasites
- Resource Type:
- Courseware