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Video
Armed with a sense of humor and laypeople's terms, Nobel winner Murray Gell-Mann drops some knowledge on TEDsters about particle physics, asking questions like, Are elegant equations more likely to be right than inelegant ones?
- Subjects:
- Physics
- Keywords:
- Particles (Nuclear physics) Physical laws
- Resource Type:
- Video
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Video
Human population growth and urbanization have accelerated dramatically in recent centuries, providing unprecedented opportunities for microbes that use our bodies as vehicles for their own propagation and transmission. These conditions have led to the emergence of virulent new pathogens and the increased prevalence of “classic” scourges, such as Mycobacterium tuberculosis. This tenacious microbe is transmitted via infectious aerosols produced by individuals with pulmonary tuberculosis. Infection is lifelong and symptomatic tuberculosis may develop following a period of clinical latency lasting for months, years, or decades. The first part of this lecture provides an overview of the natural history of TB infection and the global impact of TB on human health. Tuberculosis remains one of the most important causes of human disease and death despite the introduction of vaccination in 1921 and chemotherapy in 1952. Although these interventions are inexpensive and widely available their impact is limited. The effectiveness of vaccination is unclear; in clinical trials, the protection conferred by vaccination has been variable and generally poor. Although chemotherapy can be highly effective, multiple drugs must be administered for 6-9 months to provide a reliable cure; the majority of tuberculosis patients are unable or unwilling to complete such a demanding regimen unless closely supervised. The second part of this lecture will discuss the challenges facing development of more effective vaccines and drugs for prevention and treatment of tuberculosis. The principal obstacle to successful treatment of tuberculosis is the lengthy duration of current regimens, which require administration of multiple drugs for 6-9 months. The requirement for prolonged therapy is attributed to sub-populations of bacillary “persisters” that are refractory to antimicrobials. The persisters are not drug-resistant in the conventional (heritable) sense and it is a mystery why they are spared whilst their genetically identical siblings are killed. The third part of this lecture describes recent work in our laboratory using microfluidics and time-lapse microscopy to analyze the behavior of drug-stressed bacteria at single-cell resolution. These studies challenge conventional views of how antimicrobials kill (or fail to kill) bacteria. All pathogens must acquire and assimilate nutrients from their hosts in order to grow and multiply — our tissues are literally their food — yet surprisingly little is known about this fundamental aspect of the pathogenic lifestyle. Accumulating evidence suggests that M. tuberculosis might utilize fatty acids as its principal carbon and energy source during infection. The fourth part of this lecture describes work in our laboratory that is focused on identifying the metabolic pathways that are essential for growth and persistence of M. tuberculosis in vivo. Some of these pathways are potentially interesting targets for antimicrobial drug development, as they are not found in human cells.
- Subjects:
- Public Health and Health Sciecnes
- Keywords:
- Tuberculosis Public health
- Resource Type:
- Video
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Video
Dr. Ernest Madu runs the Heart Institute of the Caribbean in Kingston, Jamaica, where he proves that -- with careful design, smart technical choices, and a true desire to serve -- it's possible to offer world-class healthcare in the developing world.
- Subjects:
- Management of Health Care Services and Health Sciences
- Keywords:
- Health services administration
- Resource Type:
- Video
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Video
Learners watch a commercial for a fictitious product and pose questions to challenge the assumptions made in it.
- Keywords:
- Hypothesis Critical thinking
- Resource Type:
- Video
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Video
We know the negative images of Africa -- famine and disease, conflict and corruption. But, says Ngozi Okonjo-Iweala, there's another, less-told story happening in many African nations: one of reform, economic growth and business opportunity.
- Keywords:
- Businesswomen Africa Business enterprises Industrial management
- Resource Type:
- Video
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e-book
"First aid is the provision of immediate care to a victim with an injury of illness, usually effected by a lay person, and performed within a limited skill range. First aid is normally performed until the injury or illness is satisfactorily dealt with (such as in the case of small cuts, minor bruises, and blisters) or until the next level of care, such as an ambulance or doctor, arrives. This book is a Canadian version of the original at Wikibooks. All references to protocols which do not comply with resuscitation standards in Canada have been removed."--BC Campus website.
- Keywords:
- Textbooks First aid in illness injury
- Resource Type:
- e-book
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e-book
"Students need to understand systems and the systems concept, and they need to understand the role of ICT in enabling systems. Students will learn the characteristics of good systems (e.g., intuitive, likable, error-resistant, fast, flexible, and the like). Knowing the characteristics of good systems will permit students to demand well designed systems and to suggest how existing systems should be changed. Students need to understand the affordances, directions, and limits of hardware, software, and networks in both personal and organizational dimensions. They also need to appreciate that, as technical capabilities change and new ones arise, more opportunities to apply ICT for efficiency, effectiveness, and innovation are afforded. They need to understand the process for developing and implementing new or improved systems and the activities of IS professionals in this process."--BCcampus website.
- Subjects:
- Computing
- Keywords:
- Information technology Textbooks
- Resource Type:
- e-book
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e-book
Unlike some other textbooks, this one does not follow a top-down narrative. Rather it has the flow of a conversation, with backtracking. We will often build up programs incrementally, just as a pair of programmers would. We will include mistakes, not because I don't know the answer, but because this is the best way for you to learn. Including mistakes makes it impossible for you to read passively: you must instead engage with the material, because you can never be sure of the veracity of what you're reading. At the end, you'll always get to the right answer. However, this non-linear path is more frustrating in the short term (you will often be tempted to say, “Just tell me the answer, already!”), and it makes the book a poor reference guide (you can't open up to a random page and be sure what it says is correct). However, that feeling of frustration is the sensation of learning. I don't know of a way around it. At various points you will encounter this: ExerciseThis is an exercise. Do try it. This is a traditional textbook exercise. It's something you need to do on your own. If you're using this book as part of a course, this may very well have been assigned as homework. In contrast, you will also find exercise-like questions that look like this: Do Now!There's an activity here! Do you see it? When you get to one of these, stop. Read, think, and formulate an answer before you proceed. You must do this because this is actually an exercise, but the answer is already in the book—most often in the text immediately following (i.e., in the part you're reading right now)—or is something you can determine for yourself by running a program. If you just read on, you'll see the answer without having thought about it (or not see it at all, if the instructions are to run a program), so you will get to neither (a) test your knowledge, nor (b) improve your intuitions. In other words, these are additional, explicit attempts to encourage active learning. Ultimately, however, I can only encourage it; it's up to you to practice it. The main programming language used in this book is Racket. Like with all operating systems, however, Racket actually supports a host of programming languages, so you must tell Racket which language you're programming in. This textbook has been used in classes at: Brown University, Cal Poly, Columbus State University, Northeastern University, NYU, Reed College, UC-San Diego, UC-Santa Cruz, University of Rhode Island, University of Utah, Westmont College, Williams College, Worcester Polytechnic Institute.
- Subjects:
- Computing
- Keywords:
- Programming languages (Electronic computers) Textbooks
- Resource Type:
- e-book
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e-book
The title of this book is The Process of Research Writing, and in the nutshell, that is what the book is about. A lot of times, instructors and students tend to separate “thinking,” “researching,” and “writing” into different categories that aren't necessarily very well connected. First you think, then you research, and then you write.The reality is though that the possibilities and process of research writing are more complicated and much richer than that. We think about what it is we want to research and write about, but at the same time, we learn what to think based on our research and our writing. The goal of this book is to guide you through this process of research writing by emphasizing a series of exercises that touch on different and related parts of the research process.
- Subjects:
- English Language
- Keywords:
- Report writing Textbooks
- Resource Type:
- e-book
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e-book
I intend this book to be, firstly, a introduction to calculus based on the hyperrealnumber system. In other words, I will use infinitesimal and infinite numbers freely. Just as most beginning calculus books provide no logical justification for the real number system, I will provide none for the hyperreals. The reader interested in questions of foundations should consult books such asAbraham Robinson's Non-standard Analysis or Robert Goldblatt's Lectures onthe Hyperreals. Secondly, I have aimed the text primarily at readers who already have somefamiliarity with calculus. Although the book does not explicitly assume any prerequisites beyond basic algebra and trigonometry, in practice the pace istoo fast for most of those without some acquaintance with the basic notions of calculus.
- Subjects:
- Mathematics and Statistics
- Keywords:
- Calculus Textbooks
- Resource Type:
- e-book